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Home/Clinical calculators/Calculated Serum Osmolality

Clinical calculator · Nephrology

Calculated Serum Osmolality

Estimates serum osmolality from basic metabolic panel to evaluate osmolar gap and dysnatremia

Highest activation tier
Recommended
How it is scored
Scored in code; a detected disagreeing draft value is flagged for correction
Scoring type
formula
Care settings
Any setting

When it activates

Scribeable activates a calculator from the encounter. The Calculated Serum Osmolality can activate when the transcript or pasted chart context documents any of these:

  • Hyponatremia workup
  • DKA osmolality assessment
  • Hyperosmolar hyperglycemic state (HHS)
  • Toxic alcohol ingestion evaluation
  • Osmolar gap calculation

A coded diagnosis can also activate it. ICD-10 prefixes carried by the registry: E11.0, E13.1, E87.0, E87.1, T51.

  • DKA E13.10

Inputs the note needs

3 inputs. Each is resolved from the transcript, the pasted chart context and charted labs; at this calculator’s tier a missing input is never requested, and a missing required input keeps the score out of the draft.

InputTypeUnit / optionsGuidance
Serum sodium in mEq/LlabmEq/L
Serum glucose in mg/dLlabmg/dL
Blood urea nitrogen in mg/dLlabmg/dL

Reference for licensed clinicians. Where the registry text carries dose thresholds or conversion factors, they are as published in the cited sources. This page is not a prescribing tool and not individualised medical advice; verify against a current drug reference and the current guideline before acting. Medical disclaimer.

Scoring

Calculated Osm = 2×Na + glucose/18 + BUN/2.8

Formula as the note renders it

Osm = 2×Serum sodium in mEq/L + Serum glucose in mg/dL/18 + Blood urea nitrogen in mg/dL/2.8

Interpretation

Normal: 275–295 mOsm/kg. Osmolar gap (measured − calculated) >10: consider toxic alcohols (methanol, ethylene glycol), isopropanol, or unmeasured osmoles. DKA/HHS often >320. <275 with hyponatremia: hypotonic hyponatremia workup.

Evidence

Sources carried in Scribeable's citation registry for this calculator; guideline version: Standard formula.

  • Fazekas AS et al. Evaluation of 36 formulas for calculating plasma osmolalitySerum Osmolality Formula · 2013 · link last verified 2026-03-28

How Scribeable handles it in the note

When an encounter activates the Calculated Serum Osmolality (its highest tier is recommended), Scribeable does not ask you for missing inputs. The score is computed in code from whatever inputs resolve from the transcript, the pasted chart context or charted labs; a computed value is written into the draft only when every required input already resolves.

The score is computed in code from the resolved inputs, not recalled by the language model. If the draft states a Calculated Serum Osmolality value that disagrees with the computed one, the disagreement is flagged to the second drafting pass, which is instructed to correct the score and its interpretation before you see the note.

Classified as a deterministic formula: a spare suggestion is easy to ignore, so activation is permissive.

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Can activate in: Internal Medicine, Emergency Medicine, Hospital Medicine, Critical Care / ICU.

Scored in code

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