Lille Model
Predicts response to corticosteroid therapy at day 7 in severe alcoholic hepatitis; identifies non-responders who should stop steroids
Also written as: Lille Model for Alcoholic Hepatitis, Lille score, Lille, Lille Model score.
- Highest activation tier
- Recommended
- How it is scored
- Scored in code; a detected disagreeing draft value is flagged for correction
- Care settings
- ICU, Inpatient
When it activates
Scribeable activates a calculator from the encounter. The Lille Model can activate when the transcript or pasted chart context documents any of these:
- Day-7 assessment of corticosteroid response in alcoholic hepatitis
- Decision to continue vs. discontinue steroids
- Rescue therapy evaluation
A coded diagnosis can also activate it. ICD-10 prefixes carried by the registry: K70.1, K70.4.
Note-type scope: it activates on notes whose subject resolves to hepatology, gi, hospital medicine, critical care. A note that resolves to another subject does not carry it even when the clinician's specialty matches; a note with no resolvable subject (a generic consultation) falls back to the specialty match.
Inputs the note needs
6 inputs. Each is resolved from the transcript, the pasted chart context and charted labs; at this calculator’s tier a missing input is never requested, and a missing required input keeps the score out of the draft.
| Input | Type | Unit / options | Guidance |
|---|---|---|---|
| Patient age (years) | age | years | Patient age in years. |
| Serum albumin at day 0 (g/dL or g/L) | lab | g/dL | Serum albumin at day 0 of steroid therapy, in g/dL (not g/L). Typical range 1.5-5. |
| Total bilirubin at day 0 (mg/dL or umol/L) | lab | mg/dL | Total bilirubin on day 0 of steroid therapy (mg/dL). |
| Total bilirubin at day 7 of steroid therapy (mg/dL or umol/L) | lab | mg/dL | Total bilirubin on day 7 of steroid therapy (mg/dL). |
| Serum creatinine (mg/dL) | lab | mg/dL | Serum creatinine (not urine). |
| Patient's prothrombin time in seconds (not prolongation) | lab | s | Patient's prothrombin time in seconds (not prolongation or INR). |
Scoring
Logistic regression of age, albumin (g/L), bilirubin day 0 and day 7 (umol/L), creatinine, and patient PT in seconds. Range 0-1.
R = 3.19 − 0.101×Patient age (years) + 0.147×Serum albumin at day 0 (g/dL or g/L)(g/L) + 0.0165×(Total bilirubin at day 0 (mg/dL or umol/L)−Total bilirubin at day 7 of steroid therapy (mg/dL or umol/L)) − 0.206×(Cr≥1.3:Serum creatinine (mg/dL)) − 0.0065×Total bilirubin at day 0 (mg/dL or umol/L) − 0.0096×Patient's prothrombin time in seconds (not prolongation); Lille = e^(−R) / (1 + e^(−R))
Interpretation
<=0.45: Responder (6-month survival ~85%) — continue prednisolone to day 28. >0.45: Non-responder (6-month survival ~25%) — discontinue steroids, consider early liver transplant evaluation or rescue therapy (limited evidence).
Evidence
Sources carried in Scribeable's citation registry for this calculator; guideline version: Louvet A et al. 2007; AASLD 2019.
- Louvet A et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroidsLouvet et al. (Lille) 2007 · 2007 · AASLD · link last verified 2026-04-14
How Scribeable handles it in the note
When an encounter activates the Lille Model (its highest tier is recommended), Scribeable does not ask you for missing inputs. The score is computed in code from whatever inputs resolve from the transcript, the pasted chart context or charted labs; a computed value is written into the draft only when every required input already resolves.
The score is computed in code from the resolved inputs, not recalled by the language model. If the draft states a Lille Model value that disagrees with the computed one, the disagreement is flagged to the second drafting pass, which is instructed to correct the score and its interpretation before you see the note.
Classified as a risk score: activated strictly, by a documented trigger, never by a permissive reading of the encounter.
See it activate on your own encounter
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